Electrochemical Determination of Ebastine in Tablet Dosage Forms at Hanging Mercury Drop Electrode

The electrochemical behaviour of ebastine was studied at hanging mercury drop electrode using cyclic voltammetry and differential pulse voltammetry. The molecule shows a single, well defined reduction peak due to the reduction of carbonyl group. The voltammetric conditions were optimized with respect to maximum peak signals. The linearity between the peak signal and the concentration of ebastine over the concentration range of 2.0 x 10 M – 1.0 x10 M was established .The detection and quantitation limits were found to be 0.48 x 10 M and 1.60 x 10 M respectively. The developed method was employed for the determination of ebastine in tablet dosage forms.